The Science of Fetal Fibronectin

Fetal fibronectin is the single, common biochemical marker for the four mechanisms of preterm birth: activation of the maternal/fetal HPA axis, inflammation, decidual hemorrhage, and pathological uterine distention.

In the NIH Preterm Prediction Study, the abnormal presence of fetal fibronectin in vaginal secretions detected nearly two-thirds of the preterm births that occurred prior to 28 weeks.¹

Fetal fibronectin has been studied in more than 150 peer-reviewed studies involving more than 100,000 patients. Review summaries of key studies and background on the science of fetal fibronectin and preterm birth.

Reference

• 1. Goldenberg RL, et al. The Preterm Prediction Study: Fetal fibronectin testing and spontaneous preterm birth. Obstet Gynecol. 1996;87:643-8.